You will have a test on the material covered thus far this semester in class. This mostly includes the notes and associated readings or activities regarding the ‘nature of science’ and any associated terminology. This test will NOT include the chapter 7 material from your STEM book.
Test: Wednesday, 2/18/15
Read chapter 7 in your STEM book and complete the associated Google Doc in your Google Drive. You should type your answers into the yellow box underneath each question.
Due: Wednesday, 2/18/15
You should complete the study guide pages on joints given out in class by our first meeting next week. You will have a test on the notes and any associated assignments on Thursday 2/19/15 (G & H) or Friday 2/20/15 (D).
You will have a test on cancer, imperfect testing, pharmacogenetics and personalized medicine on Friday, 2/6/15. For a more specific list, see the goals and objectives handout provided in class.
Complete the ‘Ethical Issues’ section of my Pharmacogenetics page in my wiki. Answer the associated questions (on the wiki page) in your notebook. Be prepared to defend your choices regarding the case study and whether or not Elizabeth should tell her children and what her children should do if she does tell them.
On March 9, 2014, The-Scientist reported on a new screening test for Alzheimer’s disease. According to the abstract of the study,
Herein, we describe our lipidomic approach to detecting preclinical Alzheimer’s disease in a group of cognitively normal older adults. We discovered and validated a set of ten lipids from peripheral blood that predicted phenoconversion to either amnestic mild cognitive impairment or Alzheimer’s disease within a 2–3 year timeframe with over 90% accuracy. This biomarker panel, reflecting cell membrane integrity, may be sensitive to early neurodegeneration of preclinical Alzheimer’s disease.
Note the 90% accuracy claim of the test. Now that we have looked at ways to measure a test’s value (i.e. sensitivity, specificity, PPV and NPV), you might wonder what a 90% accuracy means in the context of this study. Others wondered the same thing and there are a few articles discussing this research finding in the context of medical screenings and being careful about the conclusions one should draw.
- Screen the Healthy? – read this page for a quick overview of the issue.
- How a “90% accurate” Alzheimer’s test can be wrong 92% of the time – see a good infographic here that visually displays the problem.
- On the hazards of significance testing. Part 1: the screening problem – finish by reading this page that shows the issue with screening via probability trees, Baye’s Rule, prevalence affects, and several examples. An excellent summary of many of the issues we have discussed with screening tests.
In light of our discussion about the pace of new data and knowledge, read the New Scientist article below and then comment (in the ‘Leave a Reply’ section below) on whether you think having computers search through data like this is a good thing or a bad thing and why. In your post, you should also write one thing you think the idea behind this technology could be used for beyond the medical/health field. What else could someone do with this type of analysis of data sets for good or evil?
You must also reply to at least one other post with a thoughtful comment on that person’s post. For your posts, just put your first name, the first initial of your last name, and your email so I know you did it.
Supercomputers make discoveries that scientists can’t – tech – 27 August 2014 – New Scientist.
Due: Monday, 1/26/15 by 11:59:59pm
To sign up for Remind via text or email you should follow these directions…
- You can go to www.remind.com/join and enter the class code (given in class), press enter, and then select text or email. -or-
- You can send a text message of your class code to 81010. -or-
- You can send an email to “classcode”@mail.remind.com – (no quotation marks and do not include the @ symbol that is part of the class code). You do not need anything else in the email (subject or message).
- They also have apps for your phone if you would prefer the app.
You do not have to create any accounts or logins/passwords. I will use this to send out quick reminders, quick updates, and quick links to cool stuff. You will not see my phone number and I will not see yours. You can not reply back to me from that text – it is outgoing from me to you only. If you need to contact me, send me an email. You can unsubscribe anytime by texting STOP.
**VERY IMPORTANT** – me not sending a reminder does not ever excuse you from remembering what and when things are due!!! I am just doing this to try to help.